Evidence for an ependymoma tumour suppressor gene in chromosome region 22pter–22q11.2
1999
Ependymoma Tumor Suppressor Gene on Chromosome 22
Sample size: 1
publication
Evidence: moderate
Author Information
Author(s): Hulsebos T J M, Oskam N T, Bijleveld E H, Westerveld A, Hermsen M A, Ouweland A M W van den, Hamel B C
Primary Institution: Department of Human Genetics, University of Amsterdam
Hypothesis
Is there an ependymoma tumor suppressor gene located on chromosome 22?
Conclusion
The study suggests that an ependymoma tumor suppressor gene may be present in the region 22pter–22q11.2.
Supporting Evidence
- Ependymomas are glial tumors of the brain and spinal cord.
- Monosomy 22 is the most frequent genetic change in sporadic ependymoma.
- The susceptibility gene may be located proximal to marker D22S941 in 22pter–22q11.2.
- Loss of heterozygosity studies support the presence of a tumor suppressor gene.
Takeaway
Researchers think there might be a special gene on chromosome 22 that helps prevent a type of brain tumor called ependymoma.
Methodology
Segregation analysis with chromosome 22 markers and comparative genomic hybridization.
Participant Demographics
One family with a history of ependymoma.
Digital Object Identifier (DOI)
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