Trends in Candidaemia and Antifungal Therapy in a French University Hospital
Author Information
Author(s): Sendid Boualem, Cotteau Angélique, François Nadine, D'Haveloose Annie, Standaert Annie, Camus Daniel, Poulain Daniel
Primary Institution: Inserm, U799, Lille, France
Hypothesis
The study aims to correlate candidemia incidence with the nature of prescribed antifungal drugs between 1993 and 2003.
Conclusion
The number of cases of candidemia halved between 1993 and 2000, likely linked to the use of Fluconazole prophylaxis.
Supporting Evidence
- Between 1993 and 2003, 430 blood yeast isolates were identified.
- The number of yeast isolates recovered decreased between 1995–2000.
- The prevalence of C. glabrata increased during the study period.
- Fluconazole was prescribed at prophylactic doses during the period of decreased candidemia cases.
Takeaway
The study looked at how many people got sick from a type of yeast infection in the blood and how the medicine used to treat it changed over ten years.
Methodology
A retrospective study reviewing all cases of candidemia and antifungal drug consumption over a 10-year period.
Limitations
The study did not include patients with HIV and may not represent all hospital settings.
Participant Demographics
Patients from a 3300 bed teaching hospital, with a focus on those in intensive care, surgical, cancer, gastroenterology, haematology, and paediatric services.
Digital Object Identifier (DOI)
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