Antimicrobial Preservatives in Cyclodextrin-Containing Drug Formulations
2024
Antimicrobial Preservatives in Cyclodextrin-Containing Drug Formulations
publication
Evidence: moderate
Author Information
Author(s): Phatsawee Jansook, Hákon Hrafn Sigurdsson, Frédéric Pilotaz, Thorsteinn Loftsson
Primary Institution: Chulalongkorn University
Hypothesis
How do cyclodextrins interact with antimicrobial preservatives in pharmaceutical formulations?
Conclusion
Cyclodextrins can either reduce or enhance the antimicrobial activity of preservatives in drug formulations.
Supporting Evidence
- Cyclodextrins can significantly affect the antimicrobial activity of preservatives.
- Preservatives with high hydrophilicity are less prone to inactivation by cyclodextrins.
- Excipients with antimicrobial properties can enhance preservation efficacy in formulations.
Takeaway
This study looks at how certain ingredients in medicines can help or hurt the ability of preservatives to keep germs away.
Methodology
This is a review of existing literature on the interactions between cyclodextrins and antimicrobial preservatives.
Limitations
The review does not involve new data collection or experiments.
Digital Object Identifier (DOI)
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