Detecting Amlodipine in Plasma with a New Electrochemical Probe
Author Information
Author(s): Khadivi-Derakhshan Saeedeh, Abbasi Mohammad, Akbarzadeh Amirhossein, Pirouzmand Mahtab, Soleymani Jafar
Primary Institution: Tabriz University of Medical Sciences
Hypothesis
Can a new electrochemical probe effectively detect amlodipine in unprocessed plasma samples?
Conclusion
The developed electrochemical probe is highly effective for detecting amlodipine in plasma samples.
Supporting Evidence
- The sensor showed a wide dynamic range for detecting amlodipine from 53 nM to 3.5 µM.
- It demonstrated excellent selectivity and reproducibility in detecting amlodipine.
- The method was validated for accuracy and precision in plasma samples.
Takeaway
Researchers created a special sensor that can find a medicine called amlodipine in blood samples without needing to process them first.
Methodology
The study involved modifying a glassy carbon electrode with chitosan, platinum nanocubes, and Mn(TPDCA)2 to create a sensor for detecting amlodipine.
Limitations
The complex synthesis process of Mn(TPDCA)2 and challenges in preparing stable suspensions with chitosan.
Digital Object Identifier (DOI)
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