Clindamycin Cream for Reducing Group B Strep Colonization
Author Information
Author(s): R.S. Gibbs, F. McNabb
Primary Institution: University of Colorado School of Medicine
Hypothesis
Does intravaginal 2% clindamycin cream reduce maternal and neonatal colonization of group B streptococci in pregnant women without risk factors?
Conclusion
Intravaginal 2% clindamycin cream was ineffective in reducing colonization with group B streptococci.
Supporting Evidence
- 5 out of 5 women receiving the cream remained positive for group B strep.
- 2 out of 6 neonates from women receiving the cream were positive.
- 3 out of 4 women receiving no treatment remained positive.
- 1 out of 4 neonates from women receiving no treatment was positive.
Takeaway
The study tested a cream to help pregnant women not get sick from a bacteria, but it didn't work.
Methodology
Women were randomized to receive either clindamycin cream or no treatment, and cultures were taken to test for group B streptococci.
Limitations
The study was terminated prematurely due to low effectiveness and small sample size.
Participant Demographics
All participants were pregnant women at or beyond 37 weeks gestation.
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