Protein Complexes and Pathways in Yeast Interactions
Author Information
Author(s): Casey Fergal, Krogan Nevan, Shields Denis C, Cagney Gerard
Primary Institution: University College Dublin
Hypothesis
Are specific triplet motifs in epistatic interaction networks associated with distinct biological properties?
Conclusion
NNP motifs indicate supportive relationships between protein complexes, while NPP motifs often highlight regulatory roles in biochemical pathways.
Supporting Evidence
- NNN motifs are associated with synthetic lethal interactions.
- PPP motifs correlate with protein complexes.
- NNP motifs indicate supportive relationships between protein complexes.
- NPP motifs highlight regulatory roles in biochemical pathways.
Takeaway
Scientists studied how groups of proteins interact in yeast, finding that some patterns show how proteins work together, while others show how they can oppose each other.
Methodology
The study analyzed triplet motifs in a network of epistatic interactions using a compendium of yeast genetic interactions.
Potential Biases
Potential bias from the methods used to define and analyze epistatic interactions.
Limitations
The dataset is limited to yeast and may not generalize to other organisms.
Participant Demographics
Yeast (Saccharomyces cerevisiae) genes and their interactions.
Statistical Information
P-Value
3 × 10^-6
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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