Long-term Changes in Personal Recovery and Quality of Life Among Patients With Schizophrenia Spectrum Disorders and Different Durations of Illness: A Meta-analysis
2024

Changes in Recovery and Quality of Life in Schizophrenia Patients

Sample size: 11233 publication 10 minutes Evidence: moderate

Author Information

Author(s): de Winter Lars, Jelsma Auke, Vermeulen Jentien M, van Weeghel Jaap, Hasson-Ohayon Ilanit, Mulder Cornelis L, Boonstra Nynke, Veling Wim, de Haan Lieuwe

Primary Institution: Phrenos Center of Expertise, Utrecht, the Netherlands

Hypothesis

How do personal recovery and subjective quality of life change over time in patients with schizophrenia spectrum disorders, particularly in relation to the duration of their illness?

Conclusion

Improvements in personal recovery and subjective quality of life for people with schizophrenia spectrum disorders are modest at best.

Supporting Evidence

  • Overall personal recovery showed a small improvement with an effect size of d=0.34.
  • Overall subjective quality of life also showed a small improvement with an effect size of d=0.34.
  • Connectedness and meaning in life showed marginal improvements.
  • No significant changes were found in hope and optimism or empowerment.

Takeaway

People with schizophrenia can get a little better over time, but the changes are usually small.

Methodology

The study included 46 studies that assessed changes in personal recovery and subjective quality of life over time, focusing on quantitative assessments.

Potential Biases

High risk of bias was noted in handling missing data and confounders in some studies.

Limitations

The meta-analysis was based on a limited number of studies and included different settings, which may affect the generalizability of the findings.

Participant Demographics

The mean age of participants was 37.1 years, with 37.9% being female.

Statistical Information

P-Value

p<0.05

Confidence Interval

95% CI

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1093/schbul/sbae045

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