Antibodies Against Epithelioid Cell Secretions Affect Granuloma Size
Author Information
Author(s): Mario Mariano, Tania Aguiar, Celia R. W. Carneiro, Edilberto Postolz, Vennclo A. F. Alves, Ricardo Ribeiro-dos-Santos
Primary Institution: Institute of Biomedical Sciences, University of So Paulo, SP, Brazil
Hypothesis
Epithelioid cell secreted substances, including macrophage deactivating factor (MDF), play a role in the persistence of granulomatous lesions.
Conclusion
The study found that immunoglobulins from immunized rats significantly reduced the size of BCG-induced granulomas in mice.
Supporting Evidence
- Immunoglobulins from immunized rats significantly reduced granuloma size.
- Anti-IL-10 monoclonal antibody did not block MDF activity.
- Histological examination showed necrosis of inflammatory cells in treated granulomas.
Takeaway
The researchers discovered that certain antibodies can shrink swollen areas in mice caused by infections, helping to understand how the body reacts to these infections.
Methodology
Mice were injected with BCG and treated with immunoglobulins from immunized rats, followed by measurement of granuloma size and histological examination.
Limitations
The exact mechanisms by which the immunoglobulins affect granuloma size were not determined.
Participant Demographics
Outbred mice from the Swiss strain and Cs deficient mice from the A/J strain were used.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
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