The Impact of PrEP on HIV Epidemics in Africa and India
Author Information
Author(s): Vissers Debby C. J., Voeten Hélène A. C. M., Nagelkerke Nico J. D., Habbema J. Dik F., de Vlas Sake J.
Primary Institution: Erasmus MC, University Medical Center Rotterdam
Hypothesis
What is the long-term impact of PrEP on HIV transmission in different HIV epidemics?
Conclusion
PrEP can significantly reduce HIV infections in African settings, but its effectiveness may be undermined by changes in risk behavior.
Supporting Evidence
- PrEP strategies with high effectiveness and coverage can significantly reduce HIV infections in African settings.
- In Southern India, the number of averted infections is much lower due to high levels of condom use.
- Behavioral disinhibition can diminish the effectiveness of PrEP.
- Additional condom use during PrEP can double the number of averted HIV infections.
Takeaway
PrEP is a medicine that can help prevent HIV, but if people stop using condoms because they feel safe, it might not work as well.
Methodology
A mathematical model was used to simulate the impact of different PrEP strategies on HIV transmission in Botswana, Kenya, and Southern India.
Potential Biases
Potential for behavioral disinhibition leading to increased risk-taking among PrEP users.
Limitations
The model did not account for ART treatment and its potential effects on HIV transmission.
Participant Demographics
The study focused on populations in Botswana, Nyanza Province in Kenya, and Southern India, including sex workers and their clients.
Digital Object Identifier (DOI)
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