Vascular endothelial growth factor (VEGF) upregulates BCL-2 and inhibits apoptosis in human and murine mammary adenocarcinoma cells
2001
VEGF and Its Role in Cancer Cell Survival
publication
Author Information
Author(s): Pidgeon G P, Barr M P, Harmey J H, Foley D A, Bouchier-Hayes D J
Primary Institution: Department of Surgery, Royal College of Surgeons in Ireland, Beaumont Hospital, Beaumont, Dublin 9, Ireland
Hypothesis
VEGF acts as a survival factor for tumor cells by upregulating Bcl-2 and inhibiting apoptosis.
Conclusion
VEGF not only promotes angiogenesis but also helps cancer cells survive by preventing apoptosis.
Supporting Evidence
- VEGF upregulated Bcl-2 expression in both murine and human cancer cell lines.
- Inhibition of VEGF with anti-VEGF antibodies reduced Bcl-2 expression.
- Reduced Bcl-2 expression was associated with increased apoptosis in tumor cells.
Takeaway
VEGF is like a superhero for cancer cells, helping them stay alive and grow by stopping them from dying.
Methodology
The study examined the effects of VEGF on Bcl-2 expression and apoptosis in murine and human mammary carcinoma cell lines.
Digital Object Identifier (DOI)
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