Prdm Genes and Their Role in Mouse Neurogenesis
Author Information
Author(s): Kinameri Emi, Inoue Takashi, Aruga Jun, Imayoshi Itaru, Kageyama Ryoichiro, Shimogori Tomomi, Moore Adrian W.
Primary Institution: RIKEN Brain Science Institute, Wako, Saitama, Japan
Hypothesis
The Prdm gene family may significantly participate in the development of the mammalian nervous system.
Conclusion
Prdm genes are regulated by the Notch-Hes pathway and are strong candidates for controlling neural class specification and the progression of neurogenesis.
Supporting Evidence
- Prdm genes are expressed in a spatially and temporally restricted manner in the developing mouse CNS.
- Prdm8, 12, and 13 are expressed in precise neuronal progenitor zones.
- Prdm16 expression is maintained by Notch-Hes signalling during neurogenesis.
Takeaway
This study looks at how certain genes help develop the brain in mice, showing that they work together with other signals to decide what type of nerve cells to make.
Methodology
The study used mRNA in situ hybridization (ISH) and reverse transcription polymerase chain reaction (RT-PCR) to analyze gene expression.
Digital Object Identifier (DOI)
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