Transcriptome Analysis Reveals Norathyriol Prolongs the Lifespan via Regulating Metabolism in C. elegans
2024
Norathyriol Extends Lifespan in C. elegans
Sample size: 120
publication
10 minutes
Evidence: high
Author Information
Author(s): Zhang Hong-Jia, Lan Hai-Quan, Wang Meng-Ying, Wang Cai-Feng, Wei Lu-Gang, Xu Chen
Primary Institution: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
Hypothesis
Does norathyriol influence lifespan and metabolism in C. elegans?
Conclusion
Norathyriol treatment extends the lifespan of C. elegans by 15.9% and reduces lipofuscin accumulation.
Supporting Evidence
- Norathyriol at 50 μM extends the lifespan of C. elegans by 15.9%.
- 928 differentially expressed genes were identified in NL-treated worms.
- NL treatment reduced lipofuscin accumulation in C. elegans.
- NL did not impact the feeding capabilities of C. elegans.
- Key signaling pathways associated with aging were modulated by NL.
Takeaway
This study found that a compound from mango can help worms live longer and stay healthier as they age.
Methodology
Lifespan analysis and RNA sequencing were used to evaluate the effects of norathyriol on C. elegans.
Participant Demographics
C. elegans model organism
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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