Copper Complex Helps Fight Drug-Resistant Cancer
Author Information
Author(s): Ananda Mookerjee, Jayati Basu Mookerjee, Surajit Majumder, Shilpak Chatterjee, Gouri S Panda, Pranabananda Dutta, Smarajit Pal, Pratima Mukherjee, Thomas Efferth, Syamal Roy, Soumitra K Choudhuri
Primary Institution: Chittaranjan National Cancer Institute (CNCI)
Hypothesis
Does the novel copper complex CuNG induce ROS generation and affect antioxidant enzymes in doxorubicin-resistant Ehrlich ascites carcinoma cells?
Conclusion
CuNG may be a promising candidate to sensitize drug-resistant cancers in the clinic.
Supporting Evidence
- CuNG increased ROS generation and reduced MRP1 expression in EAC/Dox cells.
- CuNG treatment restored liver and renal function in EAC/Dox bearing mice.
- CuNG modulated antioxidant enzyme activities in vital organs.
Takeaway
A new copper compound can help make some cancer cells more sensitive to treatment by increasing harmful substances in the cells and helping the body fight the cancer.
Methodology
The study involved administering CuNG to mice with doxorubicin-resistant cancer and measuring ROS generation and antioxidant enzyme activity.
Participant Demographics
Swiss albino mice, 6 weeks old, weighing 18-22 grams.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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