Genetic Links Between HK1 and Blood Sugar Levels
Author Information
Author(s): Guillaume Paré, Daniel I. Chasman, Alexander N. Parker, David M. Nathan, Joseph P. Miletich, Robert Y. Zee, Paul M. Ridker
Primary Institution: Brigham and Women's Hospital, Harvard Medical School
Hypothesis
What are the genetic determinants of glycated hemoglobin levels in non-diabetic individuals?
Conclusion
The study found that genetic variations at the HK1, GCK, SLC30A8, and G6PC2 loci are associated with glycated hemoglobin levels in non-diabetic women.
Supporting Evidence
- The study identified significant associations between glycated hemoglobin levels and genetic variants at four loci.
- The findings at HK1 are novel and suggest a role in glucose metabolism.
- The study replicated findings in an independent validation sample of 455 non-diabetic individuals.
Takeaway
Scientists looked at the genes of healthy women to see how they affect blood sugar levels, and found some important links.
Methodology
A genome-wide association study evaluating 337,343 SNPs in 14,618 non-diabetic women.
Limitations
Some diabetic subjects may not have been eliminated from the cohort, potentially affecting results.
Participant Demographics
14,618 apparently healthy Caucasian women.
Statistical Information
P-Value
p=6.4×10−9 for HK1
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website