The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria
2011
Curcumin as a Potential Treatment for Cerebral Malaria
publication
Evidence: moderate
Author Information
Author(s): Mimche Patrice N, Taramelli Donatella, Vivas Livia
Primary Institution: London School of Hygiene and Tropical Medicine
Hypothesis
Can curcumin serve as an effective adjunctive therapy for cerebral malaria by modulating the immune response?
Conclusion
Curcumin may help manage cerebral malaria by reducing inflammation and improving immune response.
Supporting Evidence
- Curcumin has shown moderate anti-malarial activity in vitro.
- It can enhance macrophage phagocytic activity.
- Curcumin reduces pro-inflammatory cytokine production.
- It has been used traditionally in Ayurvedic medicine for various disorders.
Takeaway
Curcumin, a spice from turmeric, might help treat a severe form of malaria by calming the body's immune response.
Methodology
The review discusses curcumin's properties and its potential as an adjunctive therapy based on various studies.
Limitations
Curcumin has poor bioavailability and rapid metabolism, which may hinder its clinical use.
Digital Object Identifier (DOI)
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