Multifocal Renal Cell Carcinoma: Features and Outcomes for Small Tumors
Author Information
Author(s): Crispen Paul L., Lohse Christine M., Blute Michael L.
Primary Institution: Mayo Clinic
Hypothesis
What are the clinicopathologic features and outcomes of multifocal renal cell carcinoma (RCC) in tumors that are 4 cm or smaller?
Conclusion
Multifocal RCC is present in 5.4% of patients with tumors ≤4 cm, and its presence does not lead to worse outcomes compared to solitary RCC.
Supporting Evidence
- 5.4% of patients had multifocal RCC at the time of nephrectomy.
- Discordant histology was present in 17% of patients with multifocal RCC.
- Overall survival rates were similar between multifocal and solitary RCC patients.
Takeaway
This study looked at patients with small kidney tumors and found that having multiple tumors doesn't mean you'll do worse than if you just have one.
Methodology
The study analyzed 1113 patients treated for sporadic RCC ≤4.0 cm, comparing clinical and pathologic features between those with multifocal and solitary tumors.
Potential Biases
Potential bias in patient selection and reliance on imaging for diagnosis.
Limitations
The study excluded patients with bilateral disease and relied on preoperative imaging, which may not accurately identify multifocality.
Participant Demographics
The median age at surgery was 64 years for solitary patients and 67.5 years for multifocal patients.
Statistical Information
P-Value
0.531
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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