Left Ventricular Parameters in Thalassemia Major Patients
Author Information
Author(s): Meloni Antonella, Dell'Amico Maria Chiara, Favilli Brunella, Aquaro Giovanni D, Festa Pierluigi, Chiodi Elisabetta, Renne Stefania, Galati Maria Concetta, Sardella Leonardo, Keilberg Petra, Positano Vincenzo, Lombardi Massimo, Pepe Alessia
Primary Institution: “G. Monasterio” Foundation and Institute of Clinical Physiology, CNR, Pisa, Italy
Hypothesis
What are the normal ranges for left ventricular volumes, mass, and function in well-treated Thalassemia Major patients without myocardial iron overload?
Conclusion
Significant differences in left ventricular parameters compared to controls were found only in males under 14 years and over 30 years.
Supporting Evidence
- TM patients showed significantly lower body surface area than the controls.
- Significantly higher left ventricular end-diastolic volume index and stroke volume index were found only for males aged 30 years.
- Significantly higher left ventricular ejection fraction were found only for males under 14 years.
- All left ventricular volume indexes were significantly larger in males than in females.
Takeaway
This study looked at heart measurements in kids and adults with a blood condition called Thalassemia. It found that boys under 14 and over 30 have different heart sizes compared to healthy kids and adults.
Methodology
CMR was used to evaluate left ventricular function parameters in Thalassemia Major patients and healthy controls.
Limitations
The study may not represent all Thalassemia Major patients as it only included those without known cardiac risk factors.
Participant Demographics
142 Thalassemia Major patients and 71 healthy subjects matched for age and sex.
Statistical Information
P-Value
<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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