Dalteparin Absorption in ICU Patients with Oedema
Author Information
Author(s): Rommers Mirjam K, Van Der Lely Netty, Egberts Toine CG, van den Bemt Patricia MLA
Primary Institution: St Elisabeth Hospital and TweeSteden Hospital, Tilburg, the Netherlands
Hypothesis
Does subcutaneous oedema impair the absorption of dalteparin in ICU patients?
Conclusion
There was no clinically relevant difference in anti-Xa activity after subcutaneous administration of dalteparin between ICU patients with and without subcutaneous oedema.
Supporting Evidence
- ICU patients often suffer from subcutaneous oedema due to large fluid volumes.
- Anti-Xa activity was measured at multiple time points after dalteparin administration.
- Creatinine clearance was lower in patients with subcutaneous oedema.
Takeaway
This study looked at whether swelling in ICU patients affects how well a blood thinner works when given as an injection. It found that the swelling doesn't really change how well the medicine works.
Methodology
A non-randomized open parallel group follow-up pilot study comparing anti-Xa activity in ICU patients with and without subcutaneous oedema.
Potential Biases
Potential selection bias due to exclusion of patients on vasopressors or inotropics.
Limitations
Small sample size and the study was a pilot, which may limit the generalizability of the findings.
Participant Demographics
14 ICU patients (7 with subcutaneous oedema, 7 without); age range 21-85 years.
Statistical Information
P-Value
0.003
Statistical Significance
p=0.34
Digital Object Identifier (DOI)
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