An Integrated Approach to the Prediction of Chemotherapeutic Response in Patients with Breast Cancer
2011
Retraction of Chemotherapy Response Prediction Study
publication
Author Information
Author(s): Salter Kelly H., Acharya Chaitanya R., Walters Kelli S., Redman Richard, Anguiano Ariel, Garman Katherine S., Anders Carey K., Mukherjee Sayan, Dressman Holly K., Barry William T., Marcom Kelly P., Olson John, Nevins Joseph R., Potti Anil
Primary Institution: Public Library of Science
Conclusion
The study was retracted due to errors in the labeling of clinical response in the datasets used for the original research.
Supporting Evidence
- The reexamination of validation datasets revealed errors in clinical response labeling.
- Re-analysis showed that reported signatures did not predict chemotherapy response.
- The authors of the original study decided to retract their paper.
Takeaway
The authors found mistakes in their earlier study about predicting how breast cancer patients would respond to chemotherapy, so they decided to take it back.
Limitations
Errors in the labeling of clinical response in the datasets.
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