Clinical and Laboratory Profile of Dengue Cases in Nepal
Author Information
Author(s): Eans Tara Tuladhar, Pratibha Kandel, Sujata Baidya, Smrity Rajkarnikar, Moniya Tamrakar, Gautam Rijal, Raju Kumar Dubey, Aseem Bhattarai, Mithileshwer Raut, Apeksha Niraula, Ramesh Kumar Maharjan, Vijay Kumar Sharma
Primary Institution: Tribhuvan University Teaching Hospital, Kathmandu, Nepal
Hypothesis
This study aims to describe the clinical and laboratory characteristics of dengue patients visiting a tertiary care hospital.
Conclusion
The study found significant alterations in hematological and biochemical parameters in dengue-positive cases, particularly thrombocytopenia and leukopenia.
Supporting Evidence
- 94.5% of dengue patients reported fever as a symptom.
- 51.7% of dengue-positive patients exhibited thrombocytopenia.
- Leukopenia was more severe in patients with only NS1 positive cases.
- Thrombocytopenia was more severe in patients with both IgM and NS1 positive cases.
- Elevated SGPT and SGOT levels were found in dengue-positive patients.
Takeaway
Dengue can make you very sick, and this study looked at how it affects your blood and liver. They found that many people with dengue have low blood platelets and white blood cells.
Methodology
A hospital-based cross-sectional study was conducted among 692 patients diagnosed with dengue from April 2023 to September 2023.
Potential Biases
Potential bias due to the use of convenience sampling and reliance on rapid diagnostic tests.
Limitations
The study used rapid diagnostic methods which may not be as sensitive or specific as other tests, and it could not classify patients by severity due to lack of information.
Participant Demographics
The study included 692 patients, with a slightly higher number of females (54.9%) than males (45.1%), predominantly in the age group of 20-29 years.
Statistical Information
P-Value
p ≤ 0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website