Endometrial Cancer and Oestrogen Replacement Therapy
Author Information
Author(s): A. Paganini-Hill, R.K. Ross, B.E. Henderson
Primary Institution: University of Southern California School of Medicine
Hypothesis
Does the use of oestrogen replacement therapy increase the risk of endometrial cancer in post-menopausal women?
Conclusion
The study found that women who used oestrogen replacement therapy had a significantly increased risk of endometrial cancer, especially with longer duration of use.
Supporting Evidence
- Women who used oestrogen replacement therapy had a relative risk of endometrial cancer of 10 compared to non-users.
- Risk increased significantly with longer duration of oestrogen use.
- Women who had used oestrogens for 15 or more years had a relative risk of 20 compared to non-users.
- Current and recent users had the highest risk, with a relative risk of 25.
Takeaway
Women who take hormone therapy after menopause are more likely to get a certain type of cancer called endometrial cancer, especially if they take it for a long time.
Methodology
A health survey questionnaire was mailed to residents of a retirement community, collecting data on oestrogen use and cancer diagnoses over time.
Potential Biases
Self-reported data on oestrogen use may not be entirely accurate.
Limitations
The study relied on self-reported data, which may introduce bias.
Participant Demographics
The cohort consisted of non-hysterectomised women aged 44-100 years, predominantly white and moderately affluent.
Statistical Information
P-Value
p<0.0001
Confidence Interval
95%C.I.=7.2, 54
Statistical Significance
p<0.0001
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