Neuropeptide modulation of lymphatic smooth muscle tone in the canine forelimb
1992
Effects of Neurokinin A and B on Lymphatic Resistance
Sample size: 7
publication
Evidence: moderate
Author Information
Author(s): David E. Dobbins
Primary Institution: Department of Physiology, Uniformed Services University of the Health Sciences
Hypothesis
Neurokinin A and B can alter lymphatic resistance.
Conclusion
Neurokinin A significantly increases lymphatic resistance, while neurokinin B decreases it.
Supporting Evidence
- Neurokinin A infusion significantly increased lymphatic resistance.
- Neurokinin B infusion significantly decreased lymphatic perfusion pressure.
- Both neurokinins are suggested to modulate lymphatic vessel function.
Takeaway
This study shows that certain chemicals in the body can change how well lymph vessels work, which is important for fluid movement.
Methodology
Adult mongrel dogs were anesthetized and infused with neurokinin A and B to measure changes in lymphatic perfusion pressure.
Limitations
The study was conducted on a small sample size of dogs, which may limit the generalizability of the results.
Participant Demographics
Adult mongrel dogs of either sex.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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