Thymidylate Synthase Gene Variants and Breast Cancer Risk in Chinese Women
Author Information
Author(s): Zhai Xiangjun, Gao Jun, Hu Zhibin, Tang Jinhai, Qin Jianwei, Wang Shui, Wang Xuechen, Jin Guangfu, Liu Jiyong, Chen Wenshen, Chen Feng, Wang Xinru, Wei Qingyi, Shen Hongbing
Primary Institution: Nanjing Medical University
Hypothesis
Polymorphisms of the TYMS gene are associated with risk of breast cancer.
Conclusion
The TS3'-UTR del6 polymorphism may play a role in the etiology of breast cancer.
Supporting Evidence
- The TS3'-UTR del6 genotype was associated with a significantly reduced risk of breast cancer.
- Breast cancer risks associated with the TS3'-UTR del6 genotype were more evident in older women.
- The study included 432 breast cancer cases and 473 cancer-free controls.
Takeaway
This study looked at how certain gene changes might affect the risk of getting breast cancer in women. They found that one specific gene change might help lower that risk.
Methodology
A case-control study genotyping two polymorphisms in 432 breast cancer cases and 473 controls.
Potential Biases
Potential biases due to the hospital-based nature of the case-control study.
Limitations
Lack of detailed dietary intake data and potential selection bias due to different sources for cases and controls.
Participant Demographics
All subjects were genetically-unrelated ethnic Han Chinese from Nanjing city and surrounding regions.
Statistical Information
P-Value
0.026
Confidence Interval
95% CI = 0.35–0.97
Statistical Significance
p=0.026
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website