Shape Differences in Mouse Cortical Area Maps
Author Information
Author(s): Airey David C, Wu Fangbai, Guan Monica, Collins Christine E
Primary Institution: Vanderbilt University Medical Center
Hypothesis
Are there significant shape differences in the cortical area maps of C57BL/6J and DBA/2J inbred mice?
Conclusion
C57BL/6J and DBA/2J have markedly different cortical area maps, in both size and shape.
Supporting Evidence
- Significant differences in shape in the posterior medial barrel subfield (PMBSF) were found.
- Approximately 39% of variation in shape of the PMBSF is explained by strain.
- Geometric morphometrics provides a quantitative tool for studying cortical development.
Takeaway
The brains of two types of mice look different in shape and size, which might be due to their genes.
Methodology
Geometric morphometrics was used to analyze shape differences by aligning landmarks on the cortical sheet and comparing variations.
Potential Biases
Potential bias in landmark selection and measurement accuracy.
Limitations
The study focused only on two inbred strains and may not generalize to other strains or species.
Participant Demographics
13 C57BL/6J mice and 12 DBA/2J mice, with a mix of male and female subjects.
Statistical Information
P-Value
0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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