Schistosome Infection Intensity and Auto-Reactive Antibody Levels
Author Information
Author(s): Francisca Mutapi, Natsuko Imai, Norman Nausch, Claire D. Bourke, Nadine Rujeni, Kate M. Mitchell, Midzi Nicholas, Mark E. J. Woolhouse, Rick M. Maizels, Takafira Mduluza
Primary Institution: University of Edinburgh
Hypothesis
Is there a relationship between helminth parasitism and auto-reactive antibodies in humans?
Conclusion
The study shows that higher schistosome infection intensity is associated with lower levels of auto-reactive antibodies, and that anti-helminthic treatment can significantly increase these antibody levels.
Supporting Evidence
- ANA levels were significantly lower in the high infection area compared to the low infection area.
- Post-treatment, ANA levels increased significantly in schoolchildren.
- Systemic IL-10 levels were inversely related to ANA levels.
Takeaway
People infected with certain worms have lower levels of specific antibodies that can cause autoimmune diseases, and treating these infections can increase those antibody levels.
Methodology
The study measured anti-nuclear antibodies and plasma IL-10 levels in 613 Zimbabweans exposed to Schistosoma haematobium, and followed up 102 treated schoolchildren 6 months post-treatment.
Limitations
The study did not include untreated controls due to high infection levels requiring treatment for all participants.
Participant Demographics
Participants were aged 2–86 years, with a mix of genders and HIV statuses.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI: 63% to 75%
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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