Th17 Lymphocytes and Monocytes in Sepsis
Author Information
Author(s): Salomão R, Brunialti M, Santos M, Rigato O, Machado F, Silva E
Primary Institution: Escola Paulista de Medicina, UNIFESP, São Paulo - SP, Brazil
Hypothesis
The study aims to evaluate the presence of specific lymphocytes and monocytes in septic patients and their association with prognosis.
Conclusion
Septic patients show a decreased proportion of Th1 and an increased proportion of Th17 lymphocytes, along with a significant increase in alternatively activated monocytes.
Supporting Evidence
- Septic patients had increased spontaneous production of IFNγ and IL-17A compared to healthy volunteers.
- The proportion of Th1 cells was lower and Th17 cells was higher in septic patients.
- Monocytes expressing CD206 and CD163 were significantly increased in septic patients.
Takeaway
In sick patients with sepsis, some immune cells change in number, which might help the body heal.
Methodology
The study involved septic patients and healthy volunteers, measuring specific immune cell types using various detection methods.
Participant Demographics
67 septic patients and 32 healthy volunteers matched for age and gender.
Digital Object Identifier (DOI)
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