Effects of Magnesium Sulphate on Microcirculation in Sepsis
Author Information
Author(s): Pranskunas Andrius, Vellinga Namkje AR, Pilvinis Vidas, Koopmans Matty, Boerma E Christiaan
Primary Institution: Hospital of Lithuanian University of Health Sciences
Hypothesis
MgS infusion may improve sublingual microcirculatory perfusion in patients with severe sepsis and septic shock.
Conclusion
After infusion of a limited and fixed dose of MgS, microcirculatory perfusion did not improve over time.
Supporting Evidence
- No significant difference in systemic hemodynamic variables was found after MgS infusion.
- Microvascular flow index did not improve after MgS infusion.
- Hospital mortality was 57% among the participants.
Takeaway
The study looked at whether magnesium could help blood flow in tiny vessels of patients with severe infections, but it didn't make a difference.
Methodology
A single-center open label study evaluating the effects of magnesium sulphate infusion on microcirculation in patients with severe sepsis and septic shock.
Limitations
The open label setting and small sample size may have masked a modest effect of MgS infusion on microcirculatory perfusion.
Participant Demographics
14 patients (12 septic shock, 2 severe sepsis) with a median age of 62 years.
Statistical Information
P-Value
0.65
Confidence Interval
2.25(1.98-2.69) vs. 2.33(1.96-2.62)
Statistical Significance
p = 0.65
Digital Object Identifier (DOI)
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