Midazolam suppresses interleukin-1β-induced interleukin-6 release from rat glial cells
2011
Midazolam Reduces IL-6 Release in Rat Glioma Cells
publication
Evidence: moderate
Author Information
Author(s): Tanabe Kumiko, Kozawa Osamu, Iida Hiroki
Primary Institution: Gifu University Graduate School of Medicine
Hypothesis
Does midazolam suppress IL-1β-induced IL-6 release from rat glial cells?
Conclusion
Midazolam inhibits IL-1β-induced IL-6 release in rat C6 glioma cells by suppressing STAT3 activation.
Supporting Evidence
- Midazolam significantly suppressed IL-1β-induced IL-6 release.
- The suppressive effect of midazolam was concentration-dependent.
- Midazolam inhibited IL-1β-induced STAT3 phosphorylation.
Takeaway
Midazolam helps reduce a harmful substance in brain cells that can cause inflammation, which is like stopping a fire from spreading.
Methodology
C6 glioma cells were stimulated with IL-1β, and IL-6 release was measured using ELISA; phosphorylation was analyzed by Western blotting.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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