T Cell Subsets and Mortality in Long Life Families
Author Information
Author(s): Seshadri Gokul, Vivek Sithara, Wojczynski Mary, Kuipers Allison, Zmuda Joseph, Miljkovic Iva, Ukraintseva Svetlana, Thyagarajan Bharat
Primary Institution: University of Minnesota
Hypothesis
Do T cell distributions in Long Life Family Study participants differ from the general population and how are they associated with mortality?
Conclusion
T cell subsets are maintained at older ages in long-lived families, and their association with mortality is similar to that in the general population.
Supporting Evidence
- LLFS offspring had higher levels of CD4+ naïve T cells and CD4+ effector memory cells compared to the general population.
- The percentage of CD4+ effector memory cells was associated with increased mortality risk.
- CD4+ naïve T cells showed a borderline inverse association with 4-year mortality.
Takeaway
This study looked at how different types of immune cells in older people relate to their health and how long they live.
Methodology
Measured 12 T cell subsets in LLFS offspring and spousal controls and used a Cox proportional hazards model to evaluate associations with mortality.
Participant Demographics
1647 LLFS offspring (average age 60.77 years) and 550 spousal controls (average age 61.08 years).
Statistical Information
P-Value
p=0.05; p=0.01; p=0.06
Statistical Significance
p=0.05; p=0.01; p=0.06
Digital Object Identifier (DOI)
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