Effect of a fluorinated pyrimidine on cachexia and tumour growth in murine cachexia models: relationship with a proteolysis inducing factor
2000
Effect of a fluorinated pyrimidine on cachexia and tumor growth
publication
Author Information
Author(s): Hussey H J, Todorov P T, Field W N, Inagaki N, Tanaka Y, Ishitsuka H, Tisdale M J
Primary Institution: Pharmaceutical Sciences Research Institute, Aston University, Birmingham, B4 7ET, UK
Hypothesis
The study investigates the relationship between a fluorinated pyrimidine and cachexia in murine models.
Conclusion
The fluorinated pyrimidine 5′-dFUrd can reduce cachexia and tumor growth in certain cancer models by eliminating a proteolysis-inducing factor.
Supporting Evidence
- 5′-dFUrd reduced cachexia in murine adenocarcinomas MAC16 and colon 26.
- The presence of a proteolysis-inducing factor (PIF) was linked to cachexia in the MAC16 model.
- Treatment with 5′-dFUrd eliminated PIF from the tumor, serum, and urine in mice with cachexia.
Takeaway
A special medicine helped mice with cancer not lose weight and grow tumors slower by getting rid of a harmful factor in their bodies.
Methodology
The study used murine models of adenocarcinomas and measured the effects of 5′-dFUrd on cachexia and tumor growth.
Digital Object Identifier (DOI)
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