Extra-embryonic endoderm cells derived from ES cells induced by GATA Factors acquire the character of XEN cells
2007
GATA Factors Induce XEN-like Cells from ES Cells
publication
Evidence: moderate
Author Information
Author(s): Shimosato Daisuke, Shiki Makoto, Niwa Hitoshi
Primary Institution: RIKEN Center for Developmental Biology
Hypothesis
Can GATA factors induce extra-embryonic endoderm cells from embryonic stem cells?
Conclusion
GATA factors can induce extra-embryonic endoderm cells from embryonic stem cells that resemble XEN cells.
Supporting Evidence
- GATA factors are essential for the differentiation of embryonic stem cells into extra-embryonic endoderm.
- Induced cells express markers characteristic of extra-embryonic endoderm.
- These cells can contribute to the extra-embryonic lineage in chimeric embryos.
Takeaway
Scientists found that certain proteins called GATA factors can help stem cells turn into special cells that support early development in mice.
Methodology
The study involved activating GATA factors in embryonic stem cells to observe their differentiation into extra-embryonic endoderm cells.
Limitations
The in vivo contribution of the induced cells is limited to the parietal endoderm lineage.
Digital Object Identifier (DOI)
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