The management of locally advanced breast cancer
1992
Managing Locally Advanced Breast Cancer
Sample size: 2000
Editorial
Evidence: moderate
Author Information
Author(s): R.D. Rubens
Primary Institution: ICRF Department of Clinical Oncology, UMDS, Guy's Hospital
Conclusion
Locally advanced breast cancer has a high mortality rate, but systemic treatments may improve outcomes.
Supporting Evidence
- Survival at 5 years for locally advanced breast cancer is only 20%.
- Locally advanced disease accounts for about 15% of new breast cancer cases in the UK.
- Chemotherapy before radiotherapy showed a response frequency of about 70%.
- Systemic treatment after radiotherapy has been tested in randomised controlled trials.
Takeaway
Locally advanced breast cancer is very serious, but doctors are trying different treatments to help patients live longer.
Methodology
Literature survey and analysis of treatment outcomes.
Potential Biases
There may be selection biases in the studies reviewed.
Limitations
The results from non-randomised studies should be viewed with caution due to high toxicity and potential selection biases.
Participant Demographics
Patients with locally advanced breast cancer, including those in developing countries.
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