Saliva and Serum Biomarkers in Oral Diseases
Author Information
Author(s): Al Shaar Aliaa DDS, Hamadeh Omar PhD, Ali Ayman PhD
Primary Institution: Damascus University
Hypothesis
This study aims to investigate and compare variations in salivary biomarkers with their serum counterparts in specific oral diseases such as recurrent aphthous stomatitis, lichen planus, and oral cancer.
Conclusion
The study found significant differences in salivary biomarker levels between patients with oral diseases and a control group, suggesting that saliva can be a useful diagnostic tool.
Supporting Evidence
- Salivary IgA levels were significantly higher in patients with recurrent aphthous stomatitis compared to the control group.
- Salivary cortisol levels were significantly elevated in patients with lichen planus compared to the control group.
- Salivary LDH levels were significantly higher in patients with oral cancer compared to the control group.
Takeaway
Saliva can help doctors find out if someone has certain mouth diseases by looking at special markers in it, just like they do with blood.
Methodology
A case-control study was conducted with 55 individuals, including patients with recurrent aphthous stomatitis, lichen planus, oral cancer, and a control group, analyzing saliva and serum samples for various biomarkers.
Limitations
The study's findings may not be generalizable due to the sample being sourced entirely from Syria and the limited sample size due to the COVID-19 outbreak.
Participant Demographics
Participants included 55 individuals aged 18 and above, with specific distributions among patients with recurrent aphthous stomatitis, lichen planus, oral cancer, and a control group.
Statistical Information
P-Value
P = .000, P = .016, P = .001, P = .363, P = .101, P = .048
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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