NK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells
2001
NK4 Inhibits Spreading and Invasion of Pancreatic Cancer Cells
Sample size: 8
publication
Evidence: moderate
Author Information
Author(s): Maehara N, Matsumoto K, Kuba K, Mizumoto K, Tanaka M, Nakamura T
Primary Institution: Osaka University Graduate School of Medicine
Hypothesis
Can NK4, an antagonist of HGF, inhibit the invasive properties of human pancreatic cancer cells?
Conclusion
NK4 effectively inhibits the migration and invasion of pancreatic cancer cells stimulated by HGF.
Supporting Evidence
- HGF strongly stimulated migration and invasion of pancreatic cancer cells.
- NK4 inhibited the migration and invasion induced by HGF in several pancreatic cancer cell lines.
- High levels of HGF were found in the ascitic fluid of patients after pancreatic cancer surgery.
Takeaway
This study found that a substance called NK4 can stop pancreatic cancer cells from spreading and invading other tissues.
Methodology
The study examined the effects of HGF and NK4 on eight human pancreatic cancer cell lines.
Digital Object Identifier (DOI)
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