Genome-wide search for alcohol use disorder traits
Author Information
Author(s): Rosenberger Albert, Janicke Nico, Köhler Karola, Korb Katrin, Kulle Bettina, Bickeböller Heike
Primary Institution: Georg-August University Göttingen
Hypothesis
Can different phenotypes for alcohol use disorder help identify susceptibility loci?
Conclusion
The study identified 11 candidate regions for linkage related to alcohol use disorder, but the ability to discriminate between affected and unaffected individuals was limited.
Supporting Evidence
- The study identified 11 candidate regions for linkage across 10 chromosomes.
- Only one region was found to be related to both behavioral and ERP phenotypes.
- The genome-wide search for association using SNPs did not yield significant leads.
Takeaway
Researchers looked for genes that might make people more likely to have problems with alcohol by studying different ways to measure drinking behavior and brain activity.
Methodology
The study used genome-wide linkage and association analyses with different phenotypes based on behavioral questions and ERP measures.
Limitations
The ability to discriminate between affected and unaffected individuals was poor, possibly due to a small number of informative discordant sibships and weak classification of affection status.
Participant Demographics
The study included family data on alcohol use disorders, with a focus on sex and age effects.
Statistical Information
P-Value
p = 0.027
Confidence Interval
95% CI: 11.5–63.9
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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