Foxi1 Regulates Proton Pump Subunits in Inner Ear, Kidney, and Epididymis
Author Information
Author(s): Vidarsson Hilmar, Westergren Rickard, Heglind Mikael, Blomqvist Sandra Rodrigo, Breton Sylvie, Enerbäck Sven
Primary Institution: Center of Medical Genetics, Institute of Biomedicine, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden
Hypothesis
Is Foxi1 a key regulator of proton pump subunit expression in specific epithelial cells?
Conclusion
Foxi1 is essential for the expression of multiple proton pump subunits in the inner ear, kidney, and epididymis.
Supporting Evidence
- Foxi1 is necessary for the expression of subunits A1, B1, E2, and a4 in specific epithelial cells.
- Mutations that inhibit Foxi1 interactions significantly reduce the expression of proton pump subunits.
- Foxi1 co-localizes with proton pump subunits in the inner ear, kidney, and epididymis.
Takeaway
Foxi1 helps cells in the inner ear, kidney, and epididymis make important proteins that pump protons, which are needed for various body functions.
Methodology
The study used immunohistochemistry, mRNA in situ hybridization, and reporter gene assays to analyze Foxi1's role in regulating proton pump subunits.
Digital Object Identifier (DOI)
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