HMG-CoAR Expression and Ovarian Cancer Survival
Author Information
Author(s): Brennan Donal J, Brändstedt Jenny, Rexhepaj Elton, Foley Michael, Pontén Fredrik, Uhlén Mathias, Gallagher William M, O'Connor Darran P, O'Herlihy Colm, Jirstrom Karin
Primary Institution: UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland
Hypothesis
The expression of HMG-CoAR in epithelial ovarian cancer is associated with improved recurrence-free survival.
Conclusion
HMG-CoAR expression is an independent predictor of prolonged recurrence-free survival in primary ovarian cancer.
Supporting Evidence
- HMG-CoAR expression was present in 65% of tumours.
- Patients with tumours expressing HMG-CoAR had a significantly prolonged recurrence-free survival.
- Multivariate analysis confirmed HMG-CoAR as an independent predictor of improved recurrence-free survival.
Takeaway
This study found that a protein called HMG-CoAR in ovarian cancer cells can help predict how long patients will stay cancer-free after treatment.
Methodology
HMG-CoAR expression was assessed using immunohistochemistry on tissue microarrays from 76 ovarian cancer cases, with statistical analysis performed using Kaplan Meier and Cox proportional hazards models.
Limitations
The study did not include data on statin use among patients.
Participant Demographics
Patients diagnosed with primary invasive epithelial ovarian cancer, median follow-up of 4.3 years.
Statistical Information
P-Value
0.012
Confidence Interval
95% CI (0.25-0.93)
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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