Comparing Two Methods for Defining Blood Pressure Phenotypes
Author Information
Author(s): Slager Susan L, Iturria Stephen J
Primary Institution: Mayo Clinic
Hypothesis
Our approach will provide more linkage information because all of the data, rather than summary statistics, are used to estimate the parameters in the regression model.
Conclusion
Both methods for defining blood pressure phenotypes provided similar results in terms of genetic information.
Supporting Evidence
- The two analytical methods had similar results based on LOD scores.
- Neither method reported LOD scores above 3.
- The maximum LOD score observed was 2.35 for Method 1 and 1.73 for Method 2.
- Both methods provided similar amounts of genetic information.
- The correlation between the two phenotypes used in the linkage analysis was 0.97.
Takeaway
The researchers looked at two ways to measure blood pressure over time and found that both ways gave similar results.
Methodology
The study used generalized estimating equations to analyze longitudinal data from two cohorts and compared two methods for defining phenotypes.
Potential Biases
The GEE method assumes independence among subjects, which may not hold true due to familial relationships.
Limitations
The study used real data instead of simulated data for comparison, which may not provide the most accurate results.
Participant Demographics
The study included 2885 individuals from 330 pedigrees, with data from two cohorts having different follow-up measurements.
Digital Object Identifier (DOI)
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