Differences between human breast cell lines in susceptibility towards growth inhibition by genistein
2001
Effects of Genistein on Breast Cell Growth
publication
Author Information
Author(s): Dampier K, Hudson E A, Howells L M, Manson M M, Walker R A, Gescher A
Primary Institution: MRC Toxicology Unit, University of Leicester
Hypothesis
Genistein may inhibit the growth of human breast cell lines.
Conclusion
Genistein can arrest the growth of various breast cell types, but its effects are not uniform across all cell lines.
Supporting Evidence
- Genistein stimulated growth only in MCF-7 cells at 1 μM.
- At 10 μM, genistein arrested the growth of all 6 cell types.
- Genistein induced apoptosis in only MDA-MB 468 cells.
- Cells differed in their susceptibility to genistein's effects on c-fos levels and AP-1 activity.
Takeaway
Genistein, a compound found in soya, can stop some breast cells from growing, but it works differently on different types of cells.
Methodology
The study compared the effects of genistein on several human breast cell lines.
Digital Object Identifier (DOI)
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