Risk of Rehospitalization Due to Clostridioides Difficile Infection
Author Information
Author(s): Drwiega Emily N. PharmD, Johnson Stuart MD, Danziger Larry H. PharmD, Skinner Andrew M. MD
Primary Institution: College of Pharmacy, University of Illinois Chicago
Hypothesis
What factors influence rehospitalization caused by Clostridioides difficile infection?
Conclusion
Exposure to systemic antibiotics increased the risk of rehospitalization due to CDI, while post-discharge follow-up decreased the risk.
Supporting Evidence
- All-cause rehospitalization was 46.1% within 60 days of discharge.
- 72.5% of patients who developed CDI were rehospitalized for its management.
- Post-discharge follow-up reduced the rate of rehospitalization.
Takeaway
Patients who get a certain infection while in the hospital might have to come back if they take antibiotics, but seeing a doctor after leaving the hospital can help them stay healthy.
Methodology
A retrospective cohort study assessing rehospitalization risk using a Cox proportional hazards model.
Potential Biases
Potential selection bias due to exclusion criteria.
Limitations
The study is retrospective, which may introduce unmeasured confounding.
Participant Demographics
51.2% female, median age 63 years, 45.8% immunosuppressed.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI, 1.36–5.64
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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