Serine Protease Autotransporters of Enterobacteriaceae (SPATEs): Biogenesis and Function
2010
Understanding Serine Protease Autotransporters of Enterobacteriaceae (SPATEs)
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Dautin Nathalie
Primary Institution: The Catholic University of America
Hypothesis
What are the biogenesis and functions of SPATEs in pathogenic bacteria?
Conclusion
SPATEs are a diverse family of proteases that play significant roles in the virulence of pathogenic E. coli and Shigella.
Supporting Evidence
- SPATEs are secreted by the Type Va secretion system from gram-negative bacteria.
- All SPATEs possess a conserved serine protease motif in their passenger domains.
- SPATEs have been shown to cleave various substrate proteins in vitro.
Takeaway
SPATEs are special proteins made by certain bacteria that help them cause disease by breaking down other proteins in our bodies.
Methodology
The article reviews the structure, function, and evolutionary aspects of SPATEs based on existing literature.
Limitations
The study lacks experimental data from animal models to confirm the roles of SPATEs in pathogenesis.
Digital Object Identifier (DOI)
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