Timing of Ibuprofen Use and Bone Mineral Density Adaptations to Exercise Training
Author Information
Author(s): Wendy M Kohrt, Daniel W Barry, Rachael E Van Pelt, Catherine M Jankowski, Pamela Wolfe, Robert S Schwartz
Primary Institution: University of Colorado Denver
Hypothesis
Taking ibuprofen before exercise sessions would attenuate the increases in BMD in response to exercise training when compared with taking ibuprofen after exercise sessions or with placebo treatment.
Conclusion
Taking ibuprofen immediately after exercise sessions enhances the beneficial adaptations of bone mineral density to exercise training.
Supporting Evidence
- Taking ibuprofen after exercise resulted in the largest increases in bone mineral density.
- Taking ibuprofen before exercise impaired the increases in bone mineral density.
- The study included 73 healthy premenopausal women who completed a 9-month exercise program.
- Participants were randomized into three groups based on the timing of ibuprofen and placebo administration.
Takeaway
If you take ibuprofen after exercising, it helps your bones get stronger, but taking it before might make them weaker.
Methodology
This was a randomized, double-blinded, placebo-controlled study involving healthy premenopausal women who completed a 9-month weight-bearing exercise training program.
Potential Biases
Participants were instructed to use acetaminophen for pain relief when needed, which could confound the results.
Limitations
The study was small and only included premenopausal women, which may limit the applicability of the results to other populations.
Participant Demographics
Healthy premenopausal women aged 21 to 40 years.
Statistical Information
P-Value
p = .001
Statistical Significance
p < .001
Digital Object Identifier (DOI)
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