Infections After Kidney Transplantation in Patients Treated for Glomerulonephritis
Author Information
Author(s): Massicotte-Azarniouch David MD, MSc, Detwiler Randal K. MD, Hu Yichun MS, Falk Ronald J. MD, Saha Manish K. MD, van Duin David MD, PhD, Hogan Susan L. MPH, PhD, Derebail Vimal K. MD, MPH
Primary Institution: University of North Carolina at Chapel Hill
Hypothesis
GN PTI would be associated with an increased risk for both viral and bacterial infection after transplant.
Conclusion
Use of PTI for the treatment of GN was not associated with an increased risk of viral or bacterial infection after transplantation.
Supporting Evidence
- Patients with GN PTI were not at an increased risk for developing any first viral infection compared with controls.
- GN PTI was not associated with an increased risk for specific viral infections: BK infection or CMV infection.
- There was no increased risk of developing a first bacterial infection in patients with GN PTI.
Takeaway
Patients who had kidney transplants and received treatment for kidney disease before the transplant did not have a higher chance of getting infections afterward.
Methodology
Single-center, retrospective cohort study comparing kidney transplant recipients with and without pretransplant immunosuppression.
Potential Biases
Potential for unmeasured confounding and misclassification of infections.
Limitations
Single-center study, no data on methylprednisone use for PTI, unmeasured confounding.
Participant Demographics
Mean age 43.2 years, 44.4% female, 43.9% White, 42.9% Black.
Statistical Information
Confidence Interval
95% CI, 0.52–0.91
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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