Sinonasal Neuroendocrine Carcinoma: Impact of Differentiation Status on Response and Outcome
Author Information
Author(s): Likhacheva Anna, Rosenthal David I, Hanna Ehab, Kupferman Michael, DeMonte Franco, El-Naggar Adel K
Primary Institution: The University of Texas MD Anderson Cancer Center
Hypothesis
The impact of tumor differentiation on the behavior and response of sinonasal neuroendocrine carcinoma is unknown.
Conclusion
A multimodality approach should be the cornerstone of treating sinonasal NEC regardless of their differentiation.
Supporting Evidence
- Pathologic differentiation may not be a critical factor in the clinical management of patients with NEC of the sinonasal tract.
- Multimodality approach was utilized in treatment of most patients regardless of differentiation.
- Median overall disease free survival for both groups was 23.6 months while overall survival was 58.6 months.
Takeaway
This study looked at patients with a rare type of nose cancer and found that how the cancer cells are differentiated doesn't really change how we should treat it.
Methodology
A retrospective review of patients treated for neuroendocrine carcinoma of the nasal cavity or paranasal sinuses from 1992 to 2008.
Limitations
The study is limited by its small sample size and retrospective nature.
Participant Demographics
11 men and 9 women, mean age of 49.2 years.
Digital Object Identifier (DOI)
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