Impact of Genetic Counselling on Women with Family History of Breast Cancer
Author Information
Author(s): Watson M, Lloyd S, Davidson J, Meyer L, Eeles R, Ebbs S, Murday V
Primary Institution: Royal Marsden NHS Trust and Institute of Cancer Research, UK
Hypothesis
The study investigates the perception of genetic risk and the psychological effects of genetic counselling in women with a family history of breast cancer.
Conclusion
Genetic counselling does not significantly reduce cancer-specific distress or improve general mental health in women with a family history of breast cancer.
Supporting Evidence
- 28% of participants reported worrying about breast cancer frequently or constantly before counselling.
- 18% indicated that worry about breast cancer was a severe or definite problem.
- 33% of participants were psychiatric cases detected pre-counselling.
- Only 24% could give the correct figure for population risk of breast cancer before counselling.
Takeaway
The study found that women worried a lot about breast cancer, and talking to a genetic counselor didn't really help them feel better or understand their risk better.
Methodology
The study used a prospective design with assessments pre- and post-genetic counselling at clinics and by postal follow-up at 1, 6, and 12 months.
Limitations
A significant minority of participants did not benefit from genetic counselling, and many continued to overestimate their risk.
Participant Demographics
Women with a family history of breast cancer attending four South London genetic clinics.
Statistical Information
P-Value
0.001
Statistical Significance
p=0.001
Digital Object Identifier (DOI)
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