PROGRESSION TO FRAILTY – THE ROLE OF MUSCLE RESILIENCE
2024
Muscle Resilience and Frailty in Mice
publication
Evidence: moderate
Author Information
Author(s): Thompson LaDora, Perazza Lais
Primary Institution: Boston University
Hypothesis
Robust mice would show greater resilience compared to Prefrail and Frail mice following a stressful event.
Conclusion
Resilience after acute stress is dependent on the frailty status of the mice.
Supporting Evidence
- 38% of the cohort was classified as Prefrail, 33% as Frail, and 29% as Robust.
- Tetanic force in Frail mice was significantly reduced compared to Prefrail and Robust mice.
- BMD loss occurred early in the progression to frailty.
- Robust and Prefrail mice showed a significant reduction in tetanic force after stress.
Takeaway
This study looked at how different types of mice respond to stress, finding that healthier mice handle stress better than those that are frail.
Methodology
Stress was induced by downhill running, and resilience was measured by muscle contractility and bone mineral density.
Participant Demographics
17-27-month-old C57BL/6 female mice.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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