PPARGC1A Gly482Ser Polymorphism and Diastolic Dysfunction in Men
Author Information
Author(s): Ingelsson Erik, Bennet Louise, Ridderstråle Martin, Söderström Marianne, Råstam Lennart, Lindblad Ulf
Primary Institution: Karolinska Institutet
Hypothesis
The PPARGC1A Gly482Ser polymorphism is associated with diastolic dysfunction measured by Doppler-derived diastolic filling indexes.
Conclusion
The Ser allele of the PPARGC1A Gly482Ser polymorphism was associated with decreased risk of diastolic left ventricular dysfunction in men, but not in women.
Supporting Evidence
- The Ser allele was significantly associated with a lower risk of diastolic dysfunction in men.
- The results remained significant after adjusting for confounders like age and body mass index.
- Diastolic dysfunction was prevalent in 16.5% of men and 13.0% of women in the study.
Takeaway
A specific gene variant seems to help men avoid heart problems related to how their heart fills with blood, but it doesn't help women in the same way.
Methodology
The study genotyped the PPARGC1A Gly482Ser polymorphism in a community-based cohort and evaluated its association with diastolic dysfunction using logistic regression models.
Potential Biases
There is a risk of false positive findings and lack of an independent replication sample.
Limitations
The study's generalizability to other ethnic groups is unknown, and only one polymorphism was genotyped.
Participant Demographics
499 men and 533 women aged 30 to 74 from a rural community in Sweden.
Statistical Information
P-Value
0.004
Confidence Interval
0.03–0.54
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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