Lower Levels of Lyso-Phosphatidylcholine in Cancer Patients
Author Information
Author(s): Taylor Lenka A, Arends Jann, Hodina Arwen K, Unger Clemens, Massing Ulrich
Primary Institution: Tumor Biology Center, Dept. of Clinical Research, Freiburg, Germany
Hypothesis
Decreased plasma LPC concentrations might be a general indicator for malignant disease and may allow prediction of the state of disease.
Conclusion
LPC concentrations were decreased in cancer patients and correlated with weight loss and inflammatory parameters.
Supporting Evidence
- Average plasma LPC concentration was 207 ± 59 μM, which is lower than the normal range.
- LPC correlated inversely with plasma C-reactive protein and whole blood hydrogen peroxides.
- A negative correlation was observed between LPC and whole body extracellular fluid volume.
Takeaway
Cancer patients have lower levels of a substance called LPC in their blood, which might show how serious their illness is.
Methodology
Plasma LPC concentrations were assessed using a developed HPTLC method and related to nutritional and inflammatory parameters.
Limitations
The study had a limited number of patients with severe weight loss, which may affect the generalizability of the findings.
Participant Demographics
The study included 59 cancer patients (33 women, 26 men) with a mean age of 60.6 years.
Statistical Information
P-Value
0.0000
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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