Caliber of zebrafish touch-sensory axons is dynamic in vivo
2024
Zebrafish Axon Caliber Changes Over Time
publication
Author Information
Author(s): Ching Kaitlin, Sagasti Alvaro
Primary Institution: Cold Spring Harbor Laboratory
Hypothesis
Axon caliber in zebrafish touch-sensory neurons is dynamic and varies locally in vivo.
Conclusion
The study found that axon caliber in zebrafish is not static and can change dynamically over time.
Supporting Evidence
- Axon segments showed varicose or 'pearled' morphologies.
- Caliber varied along the length of axons.
- Sister axon segments had uncorrelated calibers.
- Caliber tapered across branch points.
- Dynamicity of caliber changed during development.
- Skin cell division may influence local axon caliber.
Takeaway
Zebrafish axons can change their thickness, which might affect how they work, especially as they grow.
Methodology
The researchers used super-resolution microscopy to measure axon caliber in live zebrafish.
Participant Demographics
Zebrafish at embryonic stages.
Digital Object Identifier (DOI)
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