Risk Factors for Breast Cancer with ESR1 A908G Mutation
Author Information
Author(s): Conway Kathleen, Parrish Eloise, Edmiston Sharon N, Tolbert Dawn, Tse Chiu-Kit, Moorman Patricia, Newman Beth, Millikan Robert C
Primary Institution: University of North Carolina, Chapel Hill
Hypothesis
Are hormonal and reproductive factors associated with breast cancer characterized by the ESR1 A908G mutation?
Conclusion
The study suggests that oral contraceptives may interact with the ESR1 A908G mutant receptor to drive the development of some breast tumors.
Supporting Evidence
- ESR1 A908G mutation-positive breast cancer was significantly associated with a first-degree family history of breast cancer.
- Longer duration of oral contraceptive use was suggested to be associated with ESR1 A908G mutation-positive breast cancer.
- Mutation-negative breast cancer was associated with younger age at menarche and greater total estimated years of ovarian function.
Takeaway
This study found that using birth control pills for a long time might increase the risk of a certain type of breast cancer that has a specific mutation.
Methodology
The study evaluated risk factors for invasive breast cancer based on the presence of the ESR1 A908G mutation in a population-based case-control study.
Potential Biases
Potential bias due to the small sample size of mutation-positive cases.
Limitations
The study is limited by the small number of mutation-positive breast tumors identified.
Participant Demographics
The study included younger and older white and African-American women in North Carolina.
Statistical Information
P-Value
0.02
Confidence Interval
95% CI = 1.15 to 6.28
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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